Osteoblast behaviours on nanorod hydroxyapatite-grafted glass surfaces

So Jung Park; Kailash Chandra Gupta; Hun Kim; Sukyoung Kim; Inn-Kyu Kang

doi:10.1186/s40824-019-0178-6

Osteoblast behaviours on nanorod hydroxyapatite-grafted glass surfaces

Biomater Res. 2019 Dec 21:23:28. doi: 10.1186/s40824-019-0178-6. eCollection 2019.

Authors

So Jung Park¹, Kailash Chandra Gupta^{1

2}, Hun Kim³, Sukyoung Kim⁴, Inn-Kyu Kang¹

Affiliations

¹ 1Department of Polymer Science and Engineering, Kyungpook National University, Daegu, 702-701 South Korea.
² Department of Chemistry, Polymer Research Laboratory, I. I. T. Roorkee, Roorkee, 247 667 India.
³ Jeil Medical Corporation, Seoul, 08378 South Korea.
⁴ 4School of Materials Science and Engineering, Yeungnam University, Gyeongbuk, 712-749 South Korea.

Abstract

Background: The goal of this study is to obtain basic information to improve the bone adhesion of silica components, which are used as the main ingredient in glass ionomer cement (GIC). To achieve this, nanorod hydroxyapatite (nHA) was grafted to the surface of silica cover glass. Surface analysis confirmed nHA was joined to the glass surface and biocompatibility with osteoblasts was investigated.

Results: The grafting of nHA on the surface of slide cover glass (Glass) was confirmed by X-ray photoelectron spectroscopy (XPS) and contact angle (θ) measurement. MC3T3-E1 cells were more stretched out on the nHA-grafted cover glass (Glass-nHA) in comparison to the Glass. In addition, the Glass-nHA was more bioactive in supporting the proliferation of MC3T3-E1 cells in comparison to cells seeded on the Glass.

Conclusion: The Glass-nHA was to be highly bioactive and this might be useful information for property modification of GIC.

Keywords: Bioactive and MC3T3E1 cells; Glass; Nanorod hydroxyapatite (nHA); Surface analysis.