The anti-fatigue and anti-anoxia effects of Tremella extract

Dongsheng Yang; Junhui Lian; Lanying Wang; Xiaomei Liu; Yanzhen Wang; Xi Zhao; Xiaoming Zhang; Wenzhong Hu

doi:10.1016/j.sjbs.2019.08.014

The anti-fatigue and anti-anoxia effects of Tremella extract

Saudi J Biol Sci. 2019 Dec;26(8):2052-2056. doi: 10.1016/j.sjbs.2019.08.014. Epub 2019 Aug 14.

Authors

Dongsheng Yang^{1

2}, Junhui Lian^{1

2}, Lanying Wang^{1

2}, Xiaomei Liu^{1

2}, Yanzhen Wang^{1

2}, Xi Zhao^{1

2}, Xiaoming Zhang³, Wenzhong Hu^{1

2}

Affiliations

¹ School of Pharmacy and Food Science, Zhuhai College of Jilin University, Jinwan District, Zhuhai 519041, China.
² Sub-center of Medicine and Food Homology and Health Research, National Engineering Research Center for Modernazation of Traditional Chinese Medicine, Zhuhai 519041, China.
³ School of Chemical Engineering and New Energy Materials, Zhuhai College of Jilin University, Zhuhai 519041, China.

Abstract

Objective: The present study intended to explore the anti-fatigue and anti-hypoxia efficacy of Tremella extract in mouse model.

Methods: Kunming mice were randomized into 5 groups randomly (n = 12/group; half male and female), and given 0.9%Nacl (10 mL/Kg Serving as blank control group)orally, 0.6 g/kg rhodiola capsule (Serving as positive group) and Tremella extract at doses of high (3.0 g/kg), middle (1.5 g/kg) and low (0.5 g/kg) once a day for 14 days. At the end of drug intragastric gavage, following endurance running test, rotating rod test, normobarie hypoxia test and sodium nitrite poisoning test were performed.

Result: 14-day Tremella extract administration fails to influence mouse horizontal and vertical movement indicating little neurotoxicity at chosen doses. Through rotating rod, forced running test, the anti-fatigue activity of Tremella extract was demonstrated. Via normobarie hypoxia test, sodium nitrite poisoning test, Tremella extract was confirmed to possess anti-hypoxia effect. Tremella extract treatment significantly enhanced the liver levels of superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px), increased the expressions of ATP and hepatic glycogen, muscle glycogen in tissue.

Conclusion: We conclude that Tremella extract efficiently enhances mouse fatigue endurance and anti-hypoxia capability partly through energy reserves and antioxidant enzyme activity.

Keywords: Anti-fatigue; Anti-hypoxia; Antioxidant; Tremella.