Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging

Yongming Li; Huifei Zhong; Yanyan Huang; Rui Zhao

doi:10.3390/molecules24244593

Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging

Molecules. 2019 Dec 16;24(24):4593. doi: 10.3390/molecules24244593.

Authors

Yongming Li^{1

2}, Huifei Zhong^{1

2}, Yanyan Huang^{1

2}, Rui Zhao^{1

2}

Affiliations

¹ Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
² University of Chinese Academy of Sciences, Beijing 100049, China.

Abstract

Metal ions play important roles in biological system. Approaches capable of selective and sensitive detection of metal ions in living biosystems provide in situ information and have attracted remarkable research attentions. Among these, fluorescence probes with aggregation-induced emission (AIE) behavior offer unique properties. A variety of AIE fluorogens (AIEgens) have been developed in the past decades for tracing metal ions. This review highlights recent advances (since 2015) in AIE-based sensors for detecting metal ions in biological systems. Major concerns will be devoted to the design principles, sensing performance, and bioimaging applications.

Keywords: aggregation-induced emission; bioimaging; biosensing; metal ions.

Publication types

Review

MeSH terms

Alkalies / chemistry
Biosensing Techniques*
Fluorescence*
Fluorescent Dyes*
Ions / chemistry*
Metals / chemistry*
Molecular Imaging / methods*
Structure-Activity Relationship

Substances

Alkalies
Fluorescent Dyes
Ions
Metals

Abstract

Publication types

MeSH terms

Substances

Grants and funding