Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation

Molecules. 2019 Dec 26;25(1):99. doi: 10.3390/molecules25010099.

Abstract

Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3-8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1-8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 μg/mL and SI of 7.1.

Keywords: Clausena anisum-olens; Rutaceae; anti-HIV; carbazole alkaloids.

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology*
  • Carbazoles / chemistry
  • Carbazoles / isolation & purification
  • Carbazoles / pharmacology*
  • Cell Line
  • Clausena / chemistry*
  • HIV-1 / drug effects
  • HIV-1 / physiology*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Virus Replication / drug effects

Substances

  • Alkaloids
  • Carbazoles
  • Plant Extracts