Chemoenzymatic Halocyclization of γ,δ-Unsaturated Carboxylic Acids and Alcohols

Sabry H H Younes; Florian Tieves; Dongming Lan; Yonghua Wang; Philipp Süss; Henrike Brundiek; Ron Wever; Frank Hollmann

doi:10.1002/cssc.201903372

Chemoenzymatic Halocyclization of γ,δ-Unsaturated Carboxylic Acids and Alcohols

ChemSusChem. 2020 Jan 9;13(1):5. doi: 10.1002/cssc.201903372. Epub 2019 Dec 30.

Authors

Sabry H H Younes^{1

2}, Florian Tieves¹, Dongming Lan³, Yonghua Wang³, Philipp Süss⁴, Henrike Brundiek⁴, Ron Wever⁵, Frank Hollmann¹

Affiliations

¹ Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629, HZ, Delft, The Netherlands.
² Department of Chemistry, Faculty of Sciences, Sohag University, Sohag, 82524, Egypt.
³ School of Food Science and Engineering, Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), South China University of Technology, Guangzhou, 510640, P.R. China.
⁴ Enzymicals AG, Walther-Rathenau-Str. 49a, 17489, Greifswald, Germany.
⁵ Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, The Netherlands.

PMID: 31886621
DOI: 10.1002/cssc.201903372

Abstract

Invited for this month's cover is the group of Prof. Dr. Frank Hollmann at Delft University of Technology in the Netherlands. The Front Cover shows the vanadium-dependent haloperoxidase from the marine organism Curcuvaria inaequalis, which efficiently activates halides as hypohalites that can then initiate spontaneous halo-lactonization and halo-etherification reactions. The Communication itself is available at 10.1002/cssc.201902240.