Etiology of Renal Replacement Therapy in Iran

Negar Morovatdar; Gholamreza Tayebi Nasrabad; Konstantinos Tsarouhas; Ramin Rezaee

doi:10.1155/2019/5010293

Etiology of Renal Replacement Therapy in Iran

Int J Nephrol. 2019 Nov 26:2019:5010293. doi: 10.1155/2019/5010293. eCollection 2019.

Authors

Negar Morovatdar¹, Gholamreza Tayebi Nasrabad², Konstantinos Tsarouhas^{3

4}, Ramin Rezaee^{1

5}

Affiliations

¹ Clinical Research Unit, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
² Treatment Affair of Vice Chancellery, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Department of Cardiology, University Hospital of Larissa, Larissa, Greece.
⁴ Center for Adolescent Medicine and UNESCO Chair on Adolescent Health Care, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, Athens, Greece.
⁵ Department of Chemical Engineering, Environmental Engineering Laboratory, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Abstract

Introduction: End-stage renal disease (ESRD) is one of the most common life-threatening diseases. In the past two decades, several factors were held responsible as the cause of this condition. The present study aimed to determine the causes of ESRD in the province of Khorasan Razavi, Iran.

Materials and methods: This cross-sectional study was conducted on 2404 ESRD patients who referred to 39 hemodialysis centers in Khorasan Razavi province, Iran, and were registered in the Mashhad University of Medical Sciences (MUMS), between 2000 and December 2018. Sociodemographic data and causes of ESRD were extracted from data registry.

Results: The mean age at onset of hemodialysis for 2404 patients was 52.8 ± 16.4 years, and 57.1% of the patients were male. Clinical profile of hypertension (28.3%) and diabetes mellitus (24.8%) were the most common known causes of ESRD in our patients. Hypertension was more prevalent in male patients compared with females (30 vs 25%, respectively) while diabetes was more prevalent in females compared with males (25.4 vs 24.4%, respectively), p=0.009. Educational level was significantly associated with the cause of ESRD (p < 0.001). Age of onset of ESRD in hypertensive patients was significantly lower compared with diabetic patients (51.5 ± 16.3 vs 58.28 ± 12.9 years, respectively; p < 0.001).

Conclusions: In the current study, the most common causes of ESRD were hypertension and diabetes mellitus. Primary prevention of hypertension and diabetes and proper treatment must be considered to reduce the burden of ESRD in Iran.