Experimental Abdominal Sepsis: Sticking to an Awkward but Still Useful Translational Model

Federica Murando; Andrea Peloso; Lorenzo Cobianchi

doi:10.1155/2019/8971036

Experimental Abdominal Sepsis: Sticking to an Awkward but Still Useful Translational Model

Mediators Inflamm. 2019 Dec 5:2019:8971036. doi: 10.1155/2019/8971036. eCollection 2019.

Authors

Federica Murando¹, Andrea Peloso^{2

3}, Lorenzo Cobianchi^{1

4}

Affiliations

¹ General Surgery Department, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
² Hepatology and Transplantation Laboratory, Department of Surgery, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
³ Divisions of Abdominal and Transplantation Surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland.
⁴ Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy.

Abstract

Animal models are widely used to replicate human intra-abdominal infections. Different methodologies have been described and proposed in the scientific literature, including injection and surgical models. The aim of this review is to recapitulate the advantages and disadvantages of each method to help choose the most appropriate model for individual experimental purposes.

Publication types

Review

MeSH terms

Animals
Disease Models, Animal*
Humans
Lipopolysaccharides / toxicity
Peritonitis / pathology
Sepsis*

Substances

Lipopolysaccharides