Knockdown RPL29 Gene Can Inhibit the Proliferation, Invasion of Squamous Cell Carcinomas

Ann Clin Lab Sci. 2019 Nov;49(6):763-769.

Abstract

Objective: Gingival squamous cell carcinoma (GSCC) is one of the most common malignancies. Endogenous ribosomal protein L29 (RPL29) has been previously proven to be up-regulated in cancer tissues. However, RPL29 expression in GSCC has not been described.

Methods: The knockdown of RPL29 gene in GSCC cells was carried out to study the influence of RPL29 silencing on GSCC cells.

Results: We investigated the influence on cell proliferation, invasion, and related biomarkers, which led us to confirm that all were repressed by the knockdown of RPL29.

Conclusion: The role of RPL29 should lead to a better understanding of the development and progression of human GSCC.

Keywords: Gingival squamous cell carcinoma (GSCC); RPL29; SCCs; cell invasion; cell proliferation.

MeSH terms

  • Adult
  • Aged
  • Apoptosis / genetics
  • Carcinoma, Squamous Cell / genetics*
  • Carcinoma, Squamous Cell / pathology*
  • Cell Proliferation / genetics
  • Gene Expression Regulation, Neoplastic
  • Gene Knockdown Techniques
  • Gingival Neoplasms / genetics*
  • Gingival Neoplasms / pathology*
  • Humans
  • Middle Aged
  • RNA, Small Interfering
  • RNA-Binding Proteins / genetics*
  • RNA-Binding Proteins / metabolism
  • Ribosomal Proteins / genetics*
  • Ribosomal Proteins / metabolism
  • Up-Regulation

Substances

  • RNA, Small Interfering
  • RNA-Binding Proteins
  • RPL29 protein, human
  • Ribosomal Proteins