Chemical constituents from Vernonia bockiana

Shi-Hui Dong; Yan Wu; Jian-Min Yue

doi:10.1016/S1875-5364(19)30114-1

Chemical constituents from Vernonia bockiana

Chin J Nat Med. 2019 Dec;17(12):924-927. doi: 10.1016/S1875-5364(19)30114-1.

Authors

Shi-Hui Dong¹, Yan Wu², Jian-Min Yue³

Affiliations

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
² State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
³ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: jmyue@simm.ac.cn.

PMID: 31882047
DOI: 10.1016/S1875-5364(19)30114-1

Abstract

A new sesquiterpenoid and two pregnane steroids, named vernobockolide C (1) and vernobockones A and B (2 and 3), respevtively, along with a known sesquiterpenoid, 7, 10-epoxy-11-hydroxy-bisabol-2-en-15-al, were isolated from the aerial part of Vernonia bockiana. Their structures were elucidated on the basis of extensive spectroscopic data analysis, especially 2D NMR (HSQC, HMBC, and ROESY). This study further expands the chemical space of this underexplored species.

Keywords: Sesquiterpenoid; Steroid; Vernonia bockiana.

MeSH terms

China
Magnetic Resonance Spectroscopy
Plant Components, Aerial / chemistry
Sesquiterpenes / chemistry*
Sesquiterpenes / isolation & purification*
Steroids / chemistry*
Steroids / isolation & purification*
Vernonia / chemistry*

Substances

Sesquiterpenes
Steroids