Highly oxygenous trichilin-type limonoids from Trichilia sinensis

Fa-Liang An; Yong Yin; Jun Luo; Ling-Yi Kong

doi:10.1016/S1875-5364(19)30112-8

Highly oxygenous trichilin-type limonoids from Trichilia sinensis

Chin J Nat Med. 2019 Dec;17(12):912-917. doi: 10.1016/S1875-5364(19)30112-8.

Authors

Fa-Liang An¹, Yong Yin¹, Jun Luo², Ling-Yi Kong³

Affiliations

¹ Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
² Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: luojun@cpu.edu.cn.
³ Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: cpu_lykong@126.com.

PMID: 31882045
DOI: 10.1016/S1875-5364(19)30112-8

Abstract

Six new trichilin-type limonoids (1-6) with C-19/29 lactol or acetal bridge and a new ring intact limonoid (7) were isolated from the desiccative ripe fruits of Trichilia sinensis. Their structures were determined by extensive spectroscopic methods including ¹H NMR, ¹³C NMR, HSQC, HMBC, ROESY experiments as well as HRESI-MS data. All isolated compounds were evaluated for toxicities against human pulmonary carcinoma A549 and Hela cell lines by sulforhodamine B (SRB) method. Compound 7 showed weak inhibitory activity in Hela cell line at 40 μmol·L^-1.

Keywords: Cytotoxic activity; Trichilia sinensis; Trichilin-type limonoids.

MeSH terms

A549 Cells
China
HeLa Cells
Humans
Limonins / chemistry*
Limonins / isolation & purification*
Magnetic Resonance Spectroscopy
Medicine, Chinese Traditional
Meliaceae / chemistry*

Substances

Limonins