Magnetic-induced graphene quantum dots for imaging-guided photothermal therapy in the second near-infrared window

Hongji Liu; Changwei Li; Yong Qian; Lin Hu; Jun Fang; Wei Tong; Rongrong Nie; Qianwang Chen; Hui Wang

doi:10.1016/j.biomaterials.2019.119700

Magnetic-induced graphene quantum dots for imaging-guided photothermal therapy in the second near-infrared window

Biomaterials. 2020 Feb:232:119700. doi: 10.1016/j.biomaterials.2019.119700. Epub 2019 Dec 18.

Authors

Hongji Liu¹, Changwei Li², Yong Qian³, Lin Hu³, Jun Fang³, Wei Tong³, Rongrong Nie⁴, Qianwang Chen⁵, Hui Wang⁶

Affiliations

¹ The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, Anhui, PR China; Hefei National Laboratory for Physical Sciences at Microscale, Department of Materials Science & Engineering, University of Science and Technology of China, Hefei, 230026, Anhui, PR China.
² Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, People's Republic of China.
³ The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, Anhui, PR China.
⁴ Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, JS, 210008, PR China. Electronic address: nrr63@nju.edu.cn.
⁵ The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, Anhui, PR China; Hefei National Laboratory for Physical Sciences at Microscale, Department of Materials Science & Engineering, University of Science and Technology of China, Hefei, 230026, Anhui, PR China. Electronic address: cqw@ustc.edu.cn.
⁶ The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, Anhui, PR China. Electronic address: hw39@hmfl.ac.cn.

PMID: 31881379
DOI: 10.1016/j.biomaterials.2019.119700

Abstract

Graphene quantum dots (GQDs) are considered emerging nanomaterials for photothermal therapy (PTT) of cancer due to their good biocompatibility and rapid excretion. However, the optical absorbance of GQDs in shorter wavelengths (<1000 nm) limits their overall therapeutic efficacies as photothermal agent in the second near infrared window (1000-1700 nm, NIR-II). Herein, we report a type of GQDs with strong absorption (1070 nm) in NIR-II region that was synthesized via a one-step solvothermal treatment using phenol as single precursor by tuning the decomposition of hydrogen peroxide under a high magnetic field with an intensity of 9T. The obtained 9T-GQDs demonstrate uniform size distribution (3.6 nm), and tunable fluorescence (quantum yield, 16.67%) and high photothermal conversion efficacy (33.45%). In vitro and in vivo results indicate that 9T-GQDs could efficiently ablate tumor cells and inhibit the tumor growth under NIR-II irradiation. Moreover, the 9T-GQDs exhibited enhanced NIR imaging of tumor in living mice, suggesting the great probability of using 9T-GQDs for in vivo NIR imaging-guided PTT in the NIR-II window.

Keywords: Cancer therapy; Graphene quantum dot; Magnetic field; NIR-II absorbance; Photothermal conversion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Graphite*
Magnetic Phenomena
Magnetics
Mice
Phototherapy
Photothermal Therapy*
Quantum Dots*

Substances

Graphite