Expression pattern of Syndecan-1 and HSP-70 in hip tissue of patients with osteoarthritis

Julian Kaufman; Davor Caric; Katarina Vukojevic

doi:10.1016/j.jor.2019.08.019

Expression pattern of Syndecan-1 and HSP-70 in hip tissue of patients with osteoarthritis

J Orthop. 2019 Aug 14:17:134-138. doi: 10.1016/j.jor.2019.08.019. eCollection 2020 Jan-Feb.

Authors

Julian Kaufman¹, Davor Caric², Katarina Vukojevic¹

Affiliations

¹ Department of Anatomy, Histology and Embryology. School of Medicine, University of Split, Soltanska 2, 21000, Split, Croatia.
² Department of Orthopedic Surgery and Traumatology, KBC Split - Krizine, Soltanska 1, 21000, Split, Croatia.

Abstract

Objectives: We investigated the expression of Syndecan-1 and HSP-70 in synovial, chondral and subchondral tissue in the hips of patients with osteoarthritis (OA).

Methods: Total hip arthroplasty was performed on 6 patients and 3 controls. Patients were divided into two groups according to disease severity. The tissues were immunohistochemically analyzed.

Results: Cartilage and subchondral tissue in patients with severe OA contained abundant positive cells with a mean positive percentage of 94,51 ± 5% and 78,95 ± 14% for Syndecan-1 and 94,42 ± 5% and 75,67 ± 17% for HSP-70, respectively.

Conclusion: In conclusion, HSP-70 and Syndecan-1 might play a role in the onset and regulation of OA in the hip.

Keywords: Cartilage; HSP-70; Hip; Osteoarthritis; Subchondral tissue; Syndecan-1.