Electrochemical Preparation of Synergistic Nanoantimicrobials

Molecules. 2019 Dec 22;25(1):49. doi: 10.3390/molecules25010049.

Abstract

The rapid spreading of resistance among common bacterial pathogens towards the misused antibiotics/disinfectant agents has drawn much attention worldwide to bacterial infections. In light of this, the present work aimed at the realization of core-shell nanoparticles possessing remarkable antimicrobial properties thanks to the synergistic action of the metal core and the disinfectant shell. Copper nanoparticles stabilized by benzalkonium chloride were prepared, characterized, and implemented in poly-vinyl-methyl ketone to obtain nanoantimicrobial composite coatings. Bioactivity tests are reported, proving the excellent disinfectant properties of the proposed nanomaterials, as compared to one of the well-known and strongest silver-based nanoantimicrobials. Applications are also briefly described.

Keywords: ETAAS; TEM; XPS; benzalkonium chloride; copper nanoparticle; nanomaterial; synergistic antimicrobial.

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Benzalkonium Compounds / chemistry*
  • Benzalkonium Compounds / pharmacology
  • Copper / chemistry*
  • Copper / pharmacology
  • Disinfectants / chemical synthesis*
  • Disinfectants / chemistry
  • Disinfectants / pharmacology
  • Escherichia coli / drug effects
  • Ketones / chemistry
  • Metal Nanoparticles
  • Microscopy, Electron, Transmission
  • Photoelectron Spectroscopy
  • Staphylococcus aureus / drug effects
  • Surface Properties

Substances

  • Anti-Bacterial Agents
  • Benzalkonium Compounds
  • Disinfectants
  • Ketones
  • Copper