Recent developments of chalcones as potential antibacterial agents in medicinal chemistry

Wenjia Dan; Jiangkun Dai

doi:10.1016/j.ejmech.2019.111980

Recent developments of chalcones as potential antibacterial agents in medicinal chemistry

Eur J Med Chem. 2020 Feb 1:187:111980. doi: 10.1016/j.ejmech.2019.111980. Epub 2019 Dec 19.

Authors

Wenjia Dan¹, Jiangkun Dai²

Affiliations

¹ Key Laboratory of Biological Medicine in Universities of Shandong Province, School of Bioscience and Technology, Weifang Medical University, Shandong, China.
² Key Laboratory of Biological Medicine in Universities of Shandong Province, School of Bioscience and Technology, Weifang Medical University, Shandong, China; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Shaanxi, China. Electronic address: daijkun@hotmail.com.

PMID: 31877539
DOI: 10.1016/j.ejmech.2019.111980

Abstract

Chalcones, containing an α,β-unsaturated ketone fragment, are an important pharmacologically active agents because of their diverse mechanisms. This review provides an update on the recent developments (2009-2019.3) in the antibacterial activity of natural and synthetic chalcones. Moreover, the structure-activity relationships and mechanisms are also carefully summarized which will provide some important guidance for design and synthesis in future. This comprehensive and critical review will be helpful for medicinal chemists to develop more candidate antibacterial agents.

Keywords: Antibacterial; Chalcone; Mechanism; Structure−activity relationships.

Publication types

Review

MeSH terms

Animals
Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Bacteria / drug effects*
Chalcones / chemical synthesis
Chalcones / chemistry
Chalcones / pharmacology*
Chemistry, Pharmaceutical
Humans
Microbial Sensitivity Tests

Substances

Anti-Bacterial Agents
Chalcones