Mucosal-associated invariant T cells restrict allergic airway inflammation

J Allergy Clin Immunol. 2020 May;145(5):1469-1473.e4. doi: 10.1016/j.jaci.2019.12.891. Epub 2019 Dec 23.

Abstract

We report that MAIT cells repress group 2 innate lymphoid cell activation and restrict allergen-induced airway inflammation and airway hyperresponsiveness.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Allergens / administration & dosage
  • Alternaria / immunology
  • Animals
  • Asthma / immunology*
  • Humans
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Middle Aged
  • Mucosal-Associated Invariant T Cells / immunology*
  • Young Adult

Substances

  • Allergens