Pro-apoptoticeffect of diterpenoids from Fokienia hodginsii on acute myeloid leukemia cells

Dang Viet Hau; Nguyen Hoang Sa; Nguyen Thanh Tam; Nguyen Thi Diep; Nguyen Thi Hoang Anh; Nguyen Thi Thuy Linh; Huynh Thi Ngoc Ni; Sabrina Adorisio; Domenico V Delfino; Trinh Thi Thuy

doi:10.1080/14786419.2019.1705818

Pro-apoptoticeffect of diterpenoids from Fokienia hodginsii on acute myeloid leukemia cells

Nat Prod Res. 2021 Nov;35(22):4685-4689. doi: 10.1080/14786419.2019.1705818. Epub 2019 Dec 24.

Authors

Dang Viet Hau¹, Nguyen Hoang Sa^{2

3}, Nguyen Thanh Tam^{1

2}, Nguyen Thi Diep², Nguyen Thi Hoang Anh^{1

2}, Nguyen Thi Thuy Linh^{1

2}, Huynh Thi Ngoc Ni⁴, Sabrina Adorisio⁵, Domenico V Delfino^{5

6}, Trinh Thi Thuy^{1

2}

Affiliations

¹ Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
² Department of Natural Products Research, Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
³ Department of Science and Technology, Khanh Hoa University, Nha Trang, Vietnam.
⁴ Department of Chemistry, Phu Yen University, Phu Yen, Vietnam.
⁵ Foligno Nursing School, University of Perugia, Perugia, Italy.
⁶ Section of Pharmacology, Department of Medicine, University of Perugia, Perugia, Italy.

PMID: 31872777
DOI: 10.1080/14786419.2019.1705818

Abstract

Previously, we isolated four known diterpenoids, trans-communic acid (1), 13-oxo-15,16-dinor-labda-8(17), 11E-diene-19-oic acid (2), 3β-hydroxytotarol (3), and totarolone (4) from Fokienia hodginsii leaves. Further study demonstrated the antiproliferative activity of all four compounds in acute myeloid leukemia (OCI-AML) cells due to impaired cell cycle progression. Interestingly, 3β-hydroxytotarol (3) had very powerful bioactivity at low concentrations (5 µg/mL).

Keywords: 3β-hydroxytotarol; Fokienia hodginsii; OCI-AML cells; antiproliferative activity; cancer; diterpene.

MeSH terms

Diterpenes* / pharmacology
Humans
Leukemia, Myeloid, Acute* / drug therapy
Plant Leaves

Substances

Diterpenes