The Short Tandem Repeat of the DMT1 Gene as a Molecular Marker of Elite Long-Distance Runners

Gerile Wuyun; Yang Hu; Zihong He; Yanchun Li; Xu Yan

doi:10.1155/2019/7064703

The Short Tandem Repeat of the DMT1 Gene as a Molecular Marker of Elite Long-Distance Runners

Int J Genomics. 2019 Nov 23:2019:7064703. doi: 10.1155/2019/7064703. eCollection 2019.

Authors

Gerile Wuyun¹, Yang Hu², Zihong He³, Yanchun Li², Xu Yan^{4

5}

Affiliations

¹ Institute of Sport, Inner Mongolia Normal University, China.
² China Institute of Sport and Health Science, Beijing Sport University, China.
³ Biology Center, China Institute of Sport Science, China.
⁴ Institute for Health and Sport, Victoria University, Australia.
⁵ Australian Institute for Musculoskeletal Sciences, Australia.

Abstract

The DMT1 gene encodes divalent metal transporter 1, a membrane iron transport protein. Divalent metal transporter 1 influences cellular iron availability, which might further affect aerobic exercise capacity. Short tandem repeat (STR) polymorphisms have been used as genetic markers in the literature, yet the STR polymorphisms of the DMT1 gene have not been well studied. In this current study, we explored the polymorphisms of the DMT1 gene in a group of elite long-distance runners and controls, by using the PCR-RFLP (Restriction Fragment Length Polymorphism) and Gene scan technology. We found that the genotype frequency of the homozygous 258 bp STR polymorphism of the DMT1 gene (258 bp/258 bp) was significantly higher in the athlete group than in the controls (χ ² = 14.01, p = 0.006) so does the allele frequency of the 258 bp STR polymorphism (χ ² = 12.867, p = 0.008). These data suggested that the STR polymorphism of the DMT1 gene might be correlated with aerobic exercise capacity and the 258 bp homozygous (25 bp/258 bp) could be used as a molecular marker for the talent identification of elite long-distance runners.