Progressive Splenomegaly and Hypersplenism: An Unusual Case of Splenic Vein Stenosis with Histologic Findings of Hepatoportal Sclerosis

Ben Freiberg; Sukru Emre; Raffaella Morotti; Brian Dillon; Alexander Koral; Shilpa M Hattangadi; Pamela L Valentino

doi:10.1016/j.jpeds.2019.11.018

Progressive Splenomegaly and Hypersplenism: An Unusual Case of Splenic Vein Stenosis with Histologic Findings of Hepatoportal Sclerosis

J Pediatr. 2020 Mar:218:222-227.e1. doi: 10.1016/j.jpeds.2019.11.018. Epub 2019 Dec 20.

Authors

Ben Freiberg¹, Sukru Emre², Raffaella Morotti³, Brian Dillon⁴, Alexander Koral⁵, Shilpa M Hattangadi⁶, Pamela L Valentino⁵

Affiliations

¹ Department of Pediatrics, Section of Pediatric Gastroenterology and Hepatology, Yale University School of Medicine, New Haven, CT. Electronic address: ben.freiberg@yale.edu.
² Department of Surgery, Section of Transplantation and Immunology, Yale University School of Medicine, New Haven, CT.
³ Department of Pathology, Yale University School of Medicine, New Haven, CT.
⁴ Department of Radiology and Biomedical Imaging, Division of Pediatric Radiology, Yale University School of Medicine, New Haven, CT.
⁵ Department of Pediatrics, Section of Pediatric Gastroenterology and Hepatology, Yale University School of Medicine, New Haven, CT.
⁶ Department of Pediatrics, Section of Hematology and Oncology, Yale University School of Medicine, New Haven, CT.

PMID: 31870607
DOI: 10.1016/j.jpeds.2019.11.018

No abstract available

Keywords: extrahepatic portal hypertension; hemolytic disorders; hepatitis; idiopathic noncirrhotic portal hypertension; infection; isolated gastric varices; left-sided portal hypertension; malignancy; vascular anomalies.

Publication types

Case Reports
Review

MeSH terms

Biopsy
Child
Constriction, Pathologic / complications
Constriction, Pathologic / diagnostic imaging*
Female
Hemolysis
Humans
Hypersplenism / complications
Hypersplenism / diagnostic imaging*
Hypertension, Portal / complications
Hypertension, Portal / diagnostic imaging
Magnetic Resonance Imaging
Portal Vein / diagnostic imaging*
Portal Vein / pathology
Sclerosis / complications
Sclerosis / diagnostic imaging*
Splenic Vein / diagnostic imaging*
Splenic Vein / pathology
Splenomegaly / complications
Splenomegaly / diagnostic imaging*
Treatment Outcome
Ultrasonography