Reduced sleep spindle activity in children with primary snoring

Abstract

Background: Habitually snoring children are at risk of manifesting disease-related problems even if their sleep studies are overall within normal limits.

Study objectives: To compare sleep spindle activity in children with primary snoring and healthy controls.

Methods: Sleep spindle activity including analysis of fast and slow spindles (ie, >13 Hz and <13 Hz, respectively) was evaluated in polysomnographic (PSG) recordings of 20 randomly selected children with primary snoring (PS; normal PSG recordings except for objective presence of snoring; 12 boys, mean age 6.5 ± 2.1 years), and 20 age- and gender-matched PSG-confirmed non-snoring controls.

Results: PS children showed significantly lower spindle indices in all non-rapid eye movement (NREM) sleep stages (p < 0.05). In contrast, fast spindles were found in 40% (n = 8) children with PS and in 25% (n = 5) controls. Sleep spindle activity was particularly higher in NREM sleep stage 2 in controls compared PS (76% versus 43% of all marked sleep spindles events in NREM sleep stage 2, p < 0.001).

Conclusions: Children with PS exhibit significantly reduced spindle activity when compared to matched controls. Reduced sleep spindle activity may be an indicator of sleep disruption and, therefore, could be involved in the development of disease-related consequences in snoring children.

Keywords: Pediatric; Sleep apnea; Sleep microstructure; Sleep spindles; Snoring.