Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region

Darlen Cardoso Carvalho; Alayde Vieira Wanderley; Fernando Augusto Rodrigues Mello Junior; André Mauricio Ribeiro Dos Santos; Luciana Pereira Colares Leitão; Tatiane Piedade de Souza; Amanda de Nazaré Cohen Lima de Castro; Leandro Lopes de Magalhães; Marianne Rodrigues Fernandes; João Augusto Nunes de Carvalho Junior; André Salim Khayat; Sidney Santos; Paulo Pimentel de Assumpção; Ney Pereira Carneiro Dos Santos

doi:10.1016/j.lrr.2019.100188

Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region

Leuk Res Rep. 2019 Nov 27:13:100188. doi: 10.1016/j.lrr.2019.100188. eCollection 2020.

Authors

Darlen Cardoso Carvalho¹, Alayde Vieira Wanderley^{1

2}, Fernando Augusto Rodrigues Mello Junior¹, André Mauricio Ribeiro Dos Santos³, Luciana Pereira Colares Leitão¹, Tatiane Piedade de Souza¹, Amanda de Nazaré Cohen Lima de Castro¹, Leandro Lopes de Magalhães³, Marianne Rodrigues Fernandes¹, João Augusto Nunes de Carvalho Junior¹, André Salim Khayat¹, Sidney Santos^{1

3}, Paulo Pimentel de Assumpção^{1

4}, Ney Pereira Carneiro Dos Santos^{1

3}

Affiliations

¹ Núcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil.
² Hospital Ophir Loyola, Departamento de Pediatria, Avenida Governador Magalhães Barata, 992, Belém, Pará CEP 66060-281, Brazil.
³ Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Cidade Universitária Prof. José Silveira Netto, Belém, Pará 01 - CEP 66075-900, Brazil.
⁴ Hospital Universitário João de Barros Barreto, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil.

Abstract

Acute Lymphoblastic Leukemia (ALL) is the most common childhood neoplasia. Studies have shown that susceptibility to ALL may be modulated by genetic variables. Our study investigated 21 genetic variants in the susceptibility of the population of the Brazilian Amazon region to B-cell ALL. The variants of the genes GGH, CEBPE, ARID5B, MTHFR and MTHFD1 were related to a protective effect against the development of ALL, whereas the variant of the gene ATIC was associated with a risk effect. The results suggest that genetic variants analyzed modulate of the risk of developing ALL in the studied population.

Keywords: ALL; Admixed; Pediatrics; Polymorphisms; Susceptibility.