Multitarget and promising role of dihydromyricetin in the treatment of metabolic diseases

Eur J Pharmacol. 2020 Mar 5:870:172888. doi: 10.1016/j.ejphar.2019.172888. Epub 2019 Dec 20.

Abstract

Dihydromyricetin (DMY or DHM), also known as ampelopsin, is the main natural flavonol compound extracted from the plant Ampelopsis grossedentata (Hand. -Mazz) W.T. Wang. In recent years, accumulating studies have been conducted to explore the extensive biological functions of DMY, including antitumor, anti-inflammation, organ-protective, and metabolic regulation effects. DMY acts as a potential preventive or therapeutic agent in treating multiple diseases, such as diabetes mellitus, atherosclerosis, nonalcoholic fatty liver disease and osteoporosis. This review article summarizes the preventive and therapeutic potential of DMY in multiple metabolic diseases and the main signaling pathways in which DMY participates to offer a comprehensive understanding and guidance for future studies.

Keywords: Ampelopsin; Atherosclerosis; Diabetes mellitus; Dihydromyricetin; Nonalcoholic fatty liver disease; Osteoporosis.

Publication types

  • Review

MeSH terms

  • Animals
  • Atherosclerosis / drug therapy
  • Diabetes Mellitus / drug therapy
  • Flavonols / pharmacology*
  • Gene Expression Regulation
  • Humans
  • Hypoglycemic Agents / pharmacology
  • Metabolic Diseases / drug therapy*
  • Non-alcoholic Fatty Liver Disease / drug therapy
  • Osteoporosis / drug therapy
  • Signal Transduction

Substances

  • Flavonols
  • Hypoglycemic Agents
  • dihydromyricetin