DNA Modification Readers and Writers and Their Interplay

Cathia Rausch; Florian D Hastert; M Cristina Cardoso

doi:10.1016/j.jmb.2019.12.018

DNA Modification Readers and Writers and Their Interplay

J Mol Biol. 2020 Mar 13;432(6):1731-1746. doi: 10.1016/j.jmb.2019.12.018. Epub 2019 Dec 20.

Authors

Cathia Rausch¹, Florian D Hastert¹, M Cristina Cardoso²

Affiliations

¹ Cell Biology and Epigenetics, Department of Biology, Technische Universität Darmstadt, 64287 Darmstadt, Germany.
² Cell Biology and Epigenetics, Department of Biology, Technische Universität Darmstadt, 64287 Darmstadt, Germany. Electronic address: cardoso@bio.tu-darmstadt.de.

PMID: 31866298
DOI: 10.1016/j.jmb.2019.12.018

Abstract

Genomic DNA is modified in a postreplicative manner and several modifications, the enzymes responsible for their deposition as well as proteins that read these modifications, have been described. Here, we focus on the impact of DNA modifications on the DNA helix and review the writers and readers of cytosine modifications and how they interplay to shape genome composition, stability, and function.

Keywords: DNA helix stability; DNA methylation readers; DNA modification writers; DNA modifications; chromatin.

Publication types

Review