Circulating irisin levels of prenatal and postnatal patients with gestational diabetes mellitus: A systematic review and meta-analysis

Lingling Cui; Tianyi Qiao; Fan Xu; Zhonglei Li; Tingting Chen; Hongli Su; Guixia Chen; Li Zhang; Dongmei Xu; Xiaofeng Zhang

doi:10.1016/j.cyto.2019.154924

Circulating irisin levels of prenatal and postnatal patients with gestational diabetes mellitus: A systematic review and meta-analysis

Cytokine. 2020 Feb:126:154924. doi: 10.1016/j.cyto.2019.154924. Epub 2019 Dec 18.

Authors

Lingling Cui¹, Tianyi Qiao², Fan Xu², Zhonglei Li², Tingting Chen², Hongli Su³, Guixia Chen³, Li Zhang³, Dongmei Xu³, Xiaofeng Zhang⁴

Affiliations

¹ Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China. Electronic address: cll@zzu.edu.cn.
² Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
³ Department of Health, The Third Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
⁴ Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China. Electronic address: ophia@163.com.

PMID: 31864100
DOI: 10.1016/j.cyto.2019.154924

Abstract

Aims: At present, there are few studies on the relationship between circulating irisin levels and gestational diabetes mellitus (GDM), and the results are inconsistent. Therefore, this study conducts a systematic review and meta-analysis to comprehensively discuss the role of irisin in the occurrence and development of GDM.

Methods: We searched the articles on the relationship between GDM and circulating irisin levels up to September 2019, using the CNKI, WANFANG-DATA, PubMed and the Web of Science databases.

Results: Twenty two articles including 3563 participants were selected in the meta-analysis. Meta-analysis found the blood irisin levels for GDM group were significantly lower than that for control group during pregnancy(SMD = -0.88, 95%CI: -1.34, -0.42, P < 0.001). However, there was no significant difference of irisin levels in the postpartum blood and cord blood between the two groups (SMD = -1.44, 95 %CI: -3.79, 0.92, P = 0.23; SMD = -0.17, 95 %CI: -0.59, 0.25, P = 0.42, respectively).

Conclusions: Compared with the control group, irisin levels in the GDM group during pregnancy are lower. However, it is no significant difference of irisin levels in the postpartum blood and cord blood. Irisin may play an important role in the occurrence and development of GDM, which needs further research to demonstrate.

Keywords: GDM; Irisin; Meta-analysis; Postnatal; Prenatal.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

MeSH terms

Diabetes, Gestational / blood*
Diabetes, Gestational / pathology
Female
Fetal Blood / chemistry
Fibronectins / blood*
Humans
Milk, Human / chemistry
Postpartum Period / blood
Pregnancy

Substances

FNDC5 protein, human
Fibronectins