Advances in dual functional antimicrobial and osteoinductive biomaterials for orthopaedic applications

Samson Afewerki; Nicole Bassous; Samarah Harb; Carlos Palo-Nieto; Guillermo U Ruiz-Esparza; Fernanda R Marciano; Thomas J Webster; André Sales Aguiar Furtado; Anderson O Lobo

doi:10.1016/j.nano.2019.102143

Advances in dual functional antimicrobial and osteoinductive biomaterials for orthopaedic applications

Nanomedicine. 2020 Feb:24:102143. doi: 10.1016/j.nano.2019.102143. Epub 2019 Dec 18.

Authors

Samson Afewerki¹, Nicole Bassous², Samarah Harb³, Carlos Palo-Nieto⁴, Guillermo U Ruiz-Esparza⁵, Fernanda R Marciano⁶, Thomas J Webster², André Sales Aguiar Furtado⁷, Anderson O Lobo⁸

Affiliations

¹ Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women´s Hospital, Cambridge, MA, USA; Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, MIT, Cambridge, MA, USA. Electronic address: samson.afewerki20@gmail.com.
² Nanomedicine Laboratory, Department of Chemical Engineering, Northeastern University, Boston, MA, USA.
³ Institute of Chemistry, São Paulo State University, Araraquara, - SP, Brazil.
⁴ Department of Medicinal Chemistry, BMC, Uppsala University, Uppsala, Sweden.
⁵ Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women´s Hospital, Cambridge, MA, USA; Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, MIT, Cambridge, MA, USA.
⁶ Department of Physics, UFPI- Federal University of Piauí, Teresina, PI, Brazil.
⁷ LIMAV - Interdisciplinary Laboratory for Advanced Materials, Department of Materials Engineering, UFPI- Federal University of Piauí, Teresina, PI, Brazil.
⁸ LIMAV - Interdisciplinary Laboratory for Advanced Materials, Department of Materials Engineering, UFPI- Federal University of Piauí, Teresina, PI, Brazil; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: lobo@ufpi.edu.br.

PMID: 31862427
DOI: 10.1016/j.nano.2019.102143

Abstract

A vast growing problem in orthopaedic medicine is the increase of clinical cases with antibiotic resistant pathogenic microbes, which is predicted to cause higher mortality than all cancers combined by 2050. Bone infectious diseases limit the healing ability of tissues and increase the risk of future injuries due to pathologic tissue remodelling. The traditional treatment for bone infections has several drawbacks and limitations, such as lengthy antibiotic treatment, extensive surgical interventions, and removal of orthopaedic implants and/or prosthesis, all of these resulting in long-term rehabilitation. This is a huge burden to the public health system resulting in increased healthcare costs. Current technologies e.g. co-delivery systems, where antibacterial and osteoinductive agents are delivered encounter challenges such as site-specific delivery, sustained and prolonged release, and biocompatibility. In this review, these aspects are highlighted to promote the invention of the next generation biomaterials to prevent and/or treat bone infections and promote tissue regeneration.

Keywords: Antibacterial; Biomaterials; Orthopedic; Osteoinduction; Tissue engineering.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / therapeutic use
Anti-Infective Agents / chemistry
Anti-Infective Agents / therapeutic use
Biocompatible Materials / chemistry*
Bone Regeneration / drug effects
Humans
Orthopedics / methods*
Osteogenesis / drug effects

Substances

Anti-Bacterial Agents
Anti-Infective Agents
Biocompatible Materials