Common neurobiological and psychological underpinnings of gambling and substance-use disorders

Prog Neuropsychopharmacol Biol Psychiatry. 2020 Apr 20:99:109847. doi: 10.1016/j.pnpbp.2019.109847. Epub 2019 Dec 17.

Abstract

Both psychological and neurobiological studies in gambling disorder have increased in the past 10-15 years. This review examines the current state of the literature, with a focus on recent magnetic resonance imaging (MRI) studies in gambling disorder. The review compares and contrasts findings across gambling and substance-use disorders. Additionally, features with arguably particular relevance to gambling disorder (e.g., "near-miss" processing) are described, as well as their relationship to choice behaviors. More broadly, the review informs on how these studies advance our understanding of brain-behavior relationships relating to decision-making and key features of addictive disorders.

Keywords: Addiction; Gambling; Near-miss; Striatum; rTMS.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anticipation, Psychological / physiology
  • Corpus Striatum / physiopathology*
  • Decision Making / physiology
  • Gambling / complications
  • Gambling / physiopathology*
  • Gambling / psychology*
  • Humans
  • Impulsive Behavior*
  • Magnetic Resonance Imaging
  • Reward*
  • Substance-Related Disorders / complications
  • Substance-Related Disorders / physiopathology*
  • Substance-Related Disorders / psychology*