Reports of L-Norvaline Toxicity in Humans May Be Greatly Overstated

Baruh Polis; Michael A Gilinsky; Abraham O Samson

doi:10.3390/brainsci9120382

Reports of L-Norvaline Toxicity in Humans May Be Greatly Overstated

Brain Sci. 2019 Dec 17;9(12):382. doi: 10.3390/brainsci9120382.

Authors

Baruh Polis¹, Michael A Gilinsky², Abraham O Samson¹

Affiliations

¹ Drug Discovery Laboratory, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.
² Scientific Research Institute of Physiology and Basic Medicine, 4 Timakova St., Novosibirsk 630117, Russia.

Abstract

Recently, a study published in "Toxicology In Vitro" (Kate Samardzic and Kenneth J. Rodgers) was entitled: "Cytotoxicity and Mitochondrial Dysfunction Caused by the Dietary Supplement L-Norvaline". The title may be greatly overstated, and here we provide several arguments showing that norvaline is not as toxic as reported.

Keywords: L-norvaline; brain; supplement; toxicity.