Association of adverse drug reaction to anti-tuberculosis medication with quality of life in patients in a tertiary referral hospital

Rev Soc Bras Med Trop. 2019 Dec 20:53:e20190207. doi: 10.1590/0037-8682-0207-2019. eCollection 2019.

Abstract

Introduction: Adverse drug reactions can develop when using anti-tuberculosis medication, and the effects of the drugs can also significantly hinder the treatment of patients.

Methods: A cross-sectional survey was conducted in 73 patients using two standardized questionnaires and the World Health Organization Quality of Life-Bref.

Results: All patients reported the presence of adverse drug reactions, 71.6% of which are minor and 28.3% both major and minor. The global quality of life analysis showed that patients with tuberculosis have a good average (67.3%).

Conclusions: There is an association between quality of life and adverse drug reaction, educational level, and vulnerability.

MeSH terms

  • Aged
  • Antitubercular Agents / administration & dosage
  • Antitubercular Agents / adverse effects*
  • Cross-Sectional Studies
  • Drug-Related Side Effects and Adverse Reactions / epidemiology*
  • Drug-Related Side Effects and Adverse Reactions / psychology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Quality of Life / psychology*
  • Socioeconomic Factors
  • Surveys and Questionnaires
  • Tertiary Care Centers
  • Tuberculosis / drug therapy*
  • Tuberculosis / psychology

Substances

  • Antitubercular Agents