Abstract
Comparison of the crystal structure of a complex of the phage 434 Cro protein and a synthetic DNA operator with the complex of the same operator and the 434 repressor DNA-binding domain shows different DNA conformations in the two structures. Binding of the protein determines the precise conformation of the DNA in each case.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Bacteriophages / genetics*
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Base Composition
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Base Sequence
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Binding Sites
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DNA, Viral / metabolism*
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DNA-Binding Proteins*
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Macromolecular Substances
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Molecular Structure
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Nucleic Acid Conformation
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Operator Regions, Genetic*
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Protein Conformation
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Repressor Proteins / metabolism*
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Transcription Factors / metabolism*
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Viral Proteins
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Viral Regulatory and Accessory Proteins
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X-Ray Diffraction
Substances
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DNA, Viral
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DNA-Binding Proteins
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Macromolecular Substances
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Repressor Proteins
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Transcription Factors
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Viral Proteins
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Viral Regulatory and Accessory Proteins
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phage repressor proteins