Structure of a phage 434 Cro/DNA complex

Nature. 1988 Oct 27;335(6193):789-95. doi: 10.1038/335789a0.

Abstract

Comparison of the crystal structure of a complex of the phage 434 Cro protein and a synthetic DNA operator with the complex of the same operator and the 434 repressor DNA-binding domain shows different DNA conformations in the two structures. Binding of the protein determines the precise conformation of the DNA in each case.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bacteriophages / genetics*
  • Base Composition
  • Base Sequence
  • Binding Sites
  • DNA, Viral / metabolism*
  • DNA-Binding Proteins*
  • Macromolecular Substances
  • Molecular Structure
  • Nucleic Acid Conformation
  • Operator Regions, Genetic*
  • Protein Conformation
  • Repressor Proteins / metabolism*
  • Transcription Factors / metabolism*
  • Viral Proteins
  • Viral Regulatory and Accessory Proteins
  • X-Ray Diffraction

Substances

  • DNA, Viral
  • DNA-Binding Proteins
  • Macromolecular Substances
  • Repressor Proteins
  • Transcription Factors
  • Viral Proteins
  • Viral Regulatory and Accessory Proteins
  • phage repressor proteins