Infectivity of Norovirus GI and GII from Bottled Mineral Water during a Waterborne Outbreak, Spain

Emerg Infect Dis. 2020 Jan;26(1):134-137. doi: 10.3201/eid2601.190778.

Abstract

During a waterborne outbreak of norovirus in Spain, we estimated 50% illness doses for a group of exposed (secretor) persons to be 556 (95% CI 319-957) genome copies/day for norovirus GI and 2,934 (95% CI 1,683-5,044) genome copies/day for norovirus GII. Use of a propidium monoazide viability assay reduced these values.

Keywords: 50% illness dose; GI; GII; Spain; bottled mineral water; dose causing illness; genotypes; infectivity; norovirus; real-time quantitative PCR; secretor status; viruses; water cooler; waterborne outbreak.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Caliciviridae Infections / epidemiology
  • Caliciviridae Infections / etiology
  • Caliciviridae Infections / virology*
  • Disease Outbreaks*
  • Gastroenteritis / epidemiology
  • Gastroenteritis / etiology
  • Gastroenteritis / virology*
  • Humans
  • Middle Aged
  • Mineral Waters / virology*
  • Norovirus* / pathogenicity
  • Spain / epidemiology
  • Waterborne Diseases / epidemiology
  • Waterborne Diseases / virology*

Substances

  • Mineral Waters