Recent Advances of Plasmonic Gold Nanoparticles in Optical Sensing and Therapy

He Zhou; Hongwei Yang; Guangke Wang; Aijun Gao; Zhiqin Yuan

doi:10.2174/1381612826666191219130033

Recent Advances of Plasmonic Gold Nanoparticles in Optical Sensing and Therapy

Curr Pharm Des. 2019;25(46):4861-4876. doi: 10.2174/1381612826666191219130033.

Authors

He Zhou¹, Hongwei Yang¹, Guangke Wang², Aijun Gao¹, Zhiqin Yuan¹

Affiliations

¹ State Key Laboratory of Chemical Resource Engineering, College of Chemistry, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
² Global Energy Interconnection Research Institute Co. Ltd, Beijing 102211, China.

PMID: 31854273
DOI: 10.2174/1381612826666191219130033

Abstract

Gold nanoparticles with special surface plasmon resonance have been widely used in sensing and therapy because of their easy preparation, unique optical properties, excellent biocompatibility, etc. The applications of gold nanoparticles in chemo/biosensing, imaging, and therapy reported in 2016-2019, are summarized in this review. Regarding the gold nanoparticle-based sensing or imaging, sensing mechanisms and strategies are provided to illustrate the concepts for designing sensitive and selective detection platforms. Gold nanoparticlemediated therapy is introduced by surface plasmon resonance-based therapy and delivery-based therapy. Beyond the sole therapeutic system, platforms through synergistic therapy are also discussed. In the end, discussion of the challenges and future trends of gold nanoparticle-based sensing and therapy systems is described.

Keywords: Gold nanoparticle; delivery; sensing; spectral analysis; surface plasmon resonance; therapy..

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biosensing Techniques*
Gold*
Humans
Metal Nanoparticles / therapeutic use*
Surface Plasmon Resonance

Substances

Gold