Drug-induced Uveitis in HIV Patients with Ocular Opportunistic Infections

Ocul Immunol Inflamm. 2020 Oct 2;28(7):1069-1075. doi: 10.1080/09273948.2019.1691240. Epub 2019 Dec 18.

Abstract

Purpose: To describe drug-induced uveitis in immunocompromised patients diagnosed with Human Immunodeficiency Virus (HIV) infection Methods: Narrative Review Results: Systemic and intraocular medications administered for the treatment of acquired immune deficiency syndrome (AIDS)-associated diseases in patients infected with HIV are a well-known cause of uveitis. Conclusions: Cidofovir and rifabutin, among other novel anti-retroviral therapies, are strongly associated with drug-induced uveitis. It is imperative to understand the pathogenesis, clinical findings, and management of HIV patients with uveitis induced by these agents.

Keywords: Drug-induced uveitis; HIV; anterior uveitis; anti-HIV treatment; antiretroviral therapy; cidofovir; rifabutin.

Publication types

  • Review

MeSH terms

  • AIDS-Related Opportunistic Infections / drug therapy*
  • AIDS-Related Opportunistic Infections / etiology
  • Anti-Bacterial Agents / adverse effects*
  • Antiviral Agents / adverse effects*
  • Cidofovir / adverse effects
  • Drug-Related Side Effects and Adverse Reactions / etiology*
  • HIV Infections / complications*
  • Humans
  • Rifabutin / adverse effects
  • Uveitis / chemically induced*

Substances

  • Anti-Bacterial Agents
  • Antiviral Agents
  • Rifabutin
  • Cidofovir