A dual-targeted CeO2-DNA nanosensor for real-time imaging of H2O2 to assess atherosclerotic plaque vulnerability

J Mater Chem B. 2020 Apr 29;8(16):3502-3505. doi: 10.1039/c9tb02459j.

Abstract

A novel dual-targeted CeO2-DNA nanosensor by modifying with folic acid (FA) and CD36 antibody was designed. This fluorescent nanosensor enables noninvasive imaging of alterations in H2O2in vitro and in vivo with good sensitivity and selectivity, accurately evaluating the inflammation level and providing early warning of plaque vulnerability.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD36 Antigens / chemistry
  • Cell Line
  • Cerium / chemistry*
  • DNA / chemistry*
  • Folic Acid / chemistry
  • Humans
  • Hydrogen Peroxide / analysis*
  • Mice
  • Nanoparticles / chemistry*
  • Optical Imaging*
  • Particle Size
  • Plaque, Atherosclerotic / diagnosis*
  • RAW 264.7 Cells
  • Surface Properties
  • Time Factors

Substances

  • CD36 Antigens
  • Cerium
  • ceric oxide
  • DNA
  • Folic Acid
  • Hydrogen Peroxide