Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019

Euro Surveill. 2019 Dec;24(50):1900734. doi: 10.2807/1560-7917.ES.2019.24.50.1900734.

Abstract

From June to October 2019, 17 patients (six infected, 11 colonised) with an extensively drug-resistant (XDR) Klebsiella pneumoniae strain were notified from four Western Pomerania medical facilities. The XDR K. pneumoniae produced carbapenemases NDM-1 and OXA-48, and was only susceptible to chloramphenicol, tigecycline and cefiderocol. Synergistic activity was observed for the combination of aztreonam plus ceftazidime-avibactam. Genomic analyses showed all isolates belonged to K. pneumoniae sequence type 307. Control measures and further investigations are ongoing.

Keywords: CTX-M; Enterobacterales; NDM-1; OXA-48; XDR; clonal spread; colistin resistance.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Bacterial Proteins
  • Cross Infection / epidemiology*
  • Disease Outbreaks*
  • Drug Resistance, Multiple, Bacterial / genetics
  • Humans
  • Klebsiella Infections / diagnosis
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / epidemiology*
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / genetics
  • Klebsiella pneumoniae / isolation & purification*
  • Microbial Sensitivity Tests
  • Sequence Analysis
  • beta-Lactamases*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • beta-Lactamases
  • beta-lactamase CTX-M-17, Klebsiella pneumoniae
  • beta-lactamase NDM-1
  • carbapenemase
  • oxacillinase