The Challenge of Bringing iPSCs to the Patient

Int J Mol Sci. 2019 Dec 13;20(24):6305. doi: 10.3390/ijms20246305.

Abstract

The implementation of induced pluripotent stem cells (iPSCs) in biomedical research more than a decade ago, resulted in a huge leap forward in the highly promising area of personalized medicine. Nowadays, we are even closer to the patient than ever. To date, there are multiple examples of iPSCs applications in clinical trials and drug screening. However, there are still many obstacles to overcome. In this review, we will focus our attention on the advantages of implementing induced pluripotent stem cells technology into the clinics but also commenting on all the current drawbacks that could hinder this promising path towards the patient.

Keywords: clinical trial; clinics; drug screening; iPSCs; induced pluripotent stem cells; personalized medicine; regenerative medicine.

Publication types

  • Review

MeSH terms

  • Cell Differentiation*
  • Humans
  • Induced Pluripotent Stem Cells / transplantation*
  • Precision Medicine / methods
  • Precision Medicine / trends*