Improving the Sensitivity of FESTA Methods for the Analysis of Fluorinated Mixtures

Anal Chem. 2020 Jan 21;92(2):2224-2228. doi: 10.1021/acs.analchem.9b04924. Epub 2020 Jan 3.

Abstract

The analysis of complex mixtures is an important but often intractable problem. When species contain sparse fluorine atoms, NMR spectra of fluorine-containing spin systems can be efficiently extracted from an intact mixture using the recently proposed FESTA (Fluorine-Edited Selective TOCSY Acquisition) methodology. Here an alternative approach to the existing selective reverse INEPT FESTA (SRI-FESTA) experiment is described, based on the use of a modulated spin echo for the initial excitation. MODO-FESTA (modulated echo FESTA) is simpler and has a significant sensitivity advantage over SRI-FESTA. Comparisons are presented of the relative sensitivity and spectral purity of the two types of methods.

Publication types

  • Research Support, Non-U.S. Gov't