Pachydermoperiostosis: A clinicopathological description

Seyed Ali Tabatabaei; Ahmad Masoomi; Mohammad Soleimani; Seyed Mohsen Rafizadeh; Mirataollah Salabati; Aliasghar Ahmadraji; Bahram Bohrani; Hossein Ghahvechian; Zohreh Nozarian

doi:10.1016/j.joco.2019.03.001

Pachydermoperiostosis: A clinicopathological description

J Curr Ophthalmol. 2019 Mar 29;31(4):450-453. doi: 10.1016/j.joco.2019.03.001. eCollection 2019 Dec.

Authors

Seyed Ali Tabatabaei¹, Ahmad Masoomi¹, Mohammad Soleimani¹, Seyed Mohsen Rafizadeh¹, Mirataollah Salabati¹, Aliasghar Ahmadraji¹, Bahram Bohrani¹, Hossein Ghahvechian¹, Zohreh Nozarian²

Affiliations

¹ Ocular Trauma and Emergency Department, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
² Pathology Department, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Purpose: To report a case of pachydermoperiostosis (PDP) and a review of the literature.

Methods: A 32-year-old man was referred to our clinic with bilateral eyelid swelling and blepharoptosis. On examination, marked blepharoptosis was noted, and his eyelids were found to be floppy. Systemic examination was significant for clubbing of digits, coarse acromegalic facial features, and furrowing and oiliness of the skin of scalp and forehead.

Results: The patient was diagnosed as a case of PDP. On the brain MRI, the pituitary gland was enlarged, and the border of clivus was irregular. Pituitary and thyroid hormone levels were normal. He underwent bilateral lateral tarsal strip (LTS) procedure to address the eyelid laxity. Histopathologic examination revealed marked sebaceous gland hyperplasia with mucin deposition in the dermis.

Conclusion: Floppy eyelid syndrome, clubbing, and acromegaloid face are main features that could lead to the diagnosis of PDP.

Keywords: Acromegaloid face; Clubbing; Floppy eyelid syndrome; Pachydermoperiostosis.

Publication types

Case Reports