Oxidative Stress and Anti-Oxidant Markers in Premature Infants with Respiratory Distress Syndrome

Enas R Abdel Hamid; Walaa H Ali; Ashraf Azmy; Hanaa H Ahmed; Lobna S Sherif; Maysa T Saleh

doi:10.3889/oamjms.2019.534

Oxidative Stress and Anti-Oxidant Markers in Premature Infants with Respiratory Distress Syndrome

Open Access Maced J Med Sci. 2019 Aug 30;7(17):2858-2863. doi: 10.3889/oamjms.2019.534. eCollection 2019 Sep 15.

Authors

Enas R Abdel Hamid¹, Walaa H Ali¹, Ashraf Azmy¹, Hanaa H Ahmed², Lobna S Sherif¹, Maysa T Saleh¹

Affiliations

¹ Child Health Department, National Research Centre, Dokki, Giza, Egypt.
² Hormones Department, National Research Centre, Dokki, Giza, Egypt.

Abstract

Background: Neonatal respiratory distress syndrome (RDS) caused by decreased surfactant and structural lung immaturity. The imbalance between oxidative status and antioxidant defence system was suggested to be an important trigger for lung affection with RDS.

Aim: The goal of the current research was to elucidate the significance of the oxidant/ antioxidant status in the pathogenesis of RDS in preterm infants.

Patients and methods: This controlled study included 31 preterm neonates with RDS and 36 healthy preterm neonates. Quantification level of oxidative stress biomarkers; malondialdehyde (MDA) & hydrogen peroxide (H₂O₂) along with antioxidant enzymes activity; catalase (CAT) & superoxide dismutase (SOD) in plasma of healthy premature neonates compared with those with RDS.

Results: status of oxidative stress markers (MDA & H₂O₂) showed a significant increase with decreased levels of antioxidant enzymes activity (CAT & SOD) in neonates with RDS when compared to healthy prematures.

Conclusion: The results obtained in this study indicate that the increased oxidative stress accompanied by reduced antioxidant defences may play a significant role in the pathogenesis of respiratory distress in preterm newborns.

Keywords: Antioxidant enzymes; Newborn; Oxidative stress; Respiratory distress disorder.