Abstract
Staphylococcus aureus is a major human pathogen that causes a wide range of infections by producing an arsenal of cytotoxins. We found that passive immunization with either a monoclonal antibody (MAb) neutralizing alpha-hemolysin or a broadly cross-reactive MAb neutralizing Panton-Valentine leukocidin, leukocidin ED, and gamma-hemolysins HlgAB and HlgCB conferred only partial protection, whereas the combination of those two MAbs conferred significant protection in a rabbit model of necrotizing pneumonia caused by the USA300 methicillin-resistant S. aureus epidemic clone.
Keywords:
Staphylococcus aureus; acute lung inflammation; necrotizing pneumonia; therapeutic antibodies.
Copyright © 2020 American Society for Microbiology.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Lung Injury / drug therapy
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Acute Lung Injury / immunology
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Acute Lung Injury / microbiology
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Animals
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Antibodies, Monoclonal / immunology*
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Antibodies, Monoclonal / therapeutic use*
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Disease Models, Animal
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Hemolysin Proteins / immunology*
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Inflammation / drug therapy
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Inflammation / immunology
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Inflammation / microbiology
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Leukocidins / therapeutic use*
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Methicillin-Resistant Staphylococcus aureus / drug effects
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Methicillin-Resistant Staphylococcus aureus / pathogenicity
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Pneumonia, Necrotizing / drug therapy*
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Pneumonia, Necrotizing / immunology*
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Rabbits
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / pathogenicity
Substances
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Antibodies, Monoclonal
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Hemolysin Proteins
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Leukocidins