Association of Mondor's disease with oral contraceptive pills

BMJ Case Rep. 2019 Dec 15;12(12):e232158. doi: 10.1136/bcr-2019-232158.

Abstract

Mondor's disease (MD) is a rare disease characterised by thrombophlebitis of superficial veins in the body. We describe a case of a 28-year-old woman with a painful cord-like lesion of the right breast (3 cm) overlying the right upper quadrant. The patient was recently prescribed metformin and oral contraceptive pills for symptomatic polycystic ovarian syndrome. Right breast ultrasound showed a tubular anechoic structure with several areas of narrowing, resembling a beaded appearance. The patient was diagnosed with MD associated with use of oral contraceptive pills. We recommended the patient to discontinue oral contraceptive because discontinuation of the causative drug is important. The patient was started on topical non-steroidal anti-inflammatory drugs and a therapeutic dose of enoxaparin. The patient showed significant clinical improvement after 5 days. At 6-week outpatient follow-up, complete resolution of the disease was noted.

Keywords: general practice/family medicine; haematology (incl blood transfusion).

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Breast Diseases / chemically induced*
  • Breast Diseases / diagnostic imaging
  • Breast Diseases / drug therapy
  • Breast Diseases / pathology
  • Contraceptives, Oral, Combined / adverse effects*
  • Contraceptives, Oral, Combined / pharmacology
  • Female
  • Heparin, Low-Molecular-Weight / administration & dosage
  • Humans
  • Thrombophlebitis / chemically induced*
  • Thrombophlebitis / diagnostic imaging
  • Thrombophlebitis / drug therapy
  • Thrombophlebitis / pathology
  • Ultrasonography

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Contraceptives, Oral, Combined
  • Heparin, Low-Molecular-Weight