Effects of fine particulate matter (PM2.5) on ovarian function and embryo quality in mice

Bao-Qiong Liao; Chao-Bin Liu; Shu-Juan Xie; Yu Liu; Ya-Bin Deng; Shu-Wen He; Xian-Pei Fu; Bin-Bin Fu; Ya-Long Wang; Ming-Huang Chen; Yan-Hong Lin; Fei-Ping Li; Xi Xie; Xin-Ru Hong; Hai-Long Wang

doi:10.1016/j.envint.2019.105338

Effects of fine particulate matter (PM_2.5) on ovarian function and embryo quality in mice

Environ Int. 2020 Feb:135:105338. doi: 10.1016/j.envint.2019.105338. Epub 2019 Dec 13.

Authors

Bao-Qiong Liao¹, Chao-Bin Liu², Shu-Juan Xie³, Yu Liu⁴, Ya-Bin Deng⁵, Shu-Wen He⁶, Xian-Pei Fu⁶, Bin-Bin Fu⁶, Ya-Long Wang⁶, Ming-Huang Chen⁶, Yan-Hong Lin⁶, Fei-Ping Li⁶, Xi Xie², Xin-Ru Hong⁷, Hai-Long Wang⁸

Affiliations

¹ Cancer Research Center, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China; Department of Reproduction and Genetics, Ganzhou Maternal and Child Health Hospital, Ganzhou, Jiangxi 341000, China; Department of Obstetrics and Gynecology, 900 Hospital of the Joint Logistics Team, Fuzhou Clinic Medical College, Fujian Medical University, Dongfang Affiliated Hospital of Xiamen University, Fuzhou, Fujian 350025, China; Organ Transplantation Institute, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
² The Fourth Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China.
³ Department of Obstetrics and Gynecology, 900 Hospital of the Joint Logistics Team, Fuzhou Clinic Medical College, Fujian Medical University, Dongfang Affiliated Hospital of Xiamen University, Fuzhou, Fujian 350025, China; Organ Transplantation Institute, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
⁴ Organ Transplantation Institute, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China; Medical College, Guangxi University, Nanning, Guangxi 530004, China.
⁵ Cancer Research Center, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
⁶ Organ Transplantation Institute, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
⁷ Department of Obstetrics and Gynecology, 900 Hospital of the Joint Logistics Team, Fuzhou Clinic Medical College, Fujian Medical University, Dongfang Affiliated Hospital of Xiamen University, Fuzhou, Fujian 350025, China. Electronic address: hxr0812@163.com.
⁸ Cancer Research Center, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China; Organ Transplantation Institute, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China; Department of Basic Medicine, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: hailongwang@xmu.edu.cn.

PMID: 31841806
DOI: 10.1016/j.envint.2019.105338

Abstract

Fine particulate matter (PM_2.5) has an adverse effect on reproductive function, in particular causing reduced male reproductive function, but relatively few studies have directly targeted its effects on female reproduction. To investigate the effects of PM_2.5 exposure on female reproduction, we exposed female mice to PM_2.5 by intratracheal instillation for 28 days, and evaluated apoptosis of ovarian granulosa cells and oocytes and the quality embryos after insemination. Our results showed increased numbers of apoptotic granulosa cells and oocytes after exposure to elevated concentrations of PM_2.5, which had adverse effects on female fertility via compromising embryo development and quality. We conclude that PM_2.5 induced apoptosis of ovarian granulosa cells and oocytes leading to disrupted embryo development and female fertility in mice.

Keywords: Embryo; Mice; Oocyte; Ovary; PM(2.5).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Air Pollutants*
Animals
Apoptosis
Female
Male
Mice
Oocytes* / drug effects
Oocytes* / growth & development
Particulate Matter* / toxicity
Reproduction

Substances

Air Pollutants
Particulate Matter