Chemotherapy after progression on nivolumab is essential for responders with genetic alterations of driver gene: Review of two recurrent/metastatic oral squamous cell carcinoma patients

Oral Oncol. 2020 Mar:102:104509. doi: 10.1016/j.oraloncology.2019.104509. Epub 2019 Dec 12.
No abstract available

Keywords: Immune check point inhibitor; Oral cancer; Somatic mutations and copy number variations.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Immunological / pharmacology
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Biomarkers, Tumor / genetics
  • Disease Progression
  • Drug Resistance, Neoplasm
  • Humans
  • Male
  • Middle Aged
  • Mouth Neoplasms / drug therapy*
  • Mouth Neoplasms / genetics*
  • Mouth Neoplasms / pathology
  • Mutation
  • Neoplasm Recurrence, Local / drug therapy*
  • Neoplasm Recurrence, Local / genetics
  • Neoplasm Recurrence, Local / pathology
  • Nivolumab / pharmacology
  • Prognosis
  • Salvage Therapy
  • Squamous Cell Carcinoma of Head and Neck / drug therapy*
  • Squamous Cell Carcinoma of Head and Neck / genetics*
  • Squamous Cell Carcinoma of Head and Neck / pathology

Substances

  • Antineoplastic Agents, Immunological
  • Biomarkers, Tumor
  • Nivolumab