Epigenetic abnormalities play an important role in the pathogenesis of hematological malignancies, especially acute leukemia (AL). Similar to DNA methylation and histone modifications, RNA methylation is another important epigenetic modification. m6A methylation is one of the most prevalent and extensively studied RNA methylation. m6A methylation is involved in many biological and pathological process. Recent studies have found that m6A methylation is involved in the occurrence, development and drug-resistance of AL. This review focuses on the research progress of m6A methylation in AL.
题目: 急性白血病m6A甲基化研究进展.
摘要: 表观遗传学异常在血液系统肿瘤，特别在急性白血病（acute leukemia, AL）中起着重要作用。RNA甲基化是类似于DNA甲基化和组蛋白修饰的另一层表观遗传学改变，其中m6A甲基化是最广泛的RNA甲基化修饰方式，贯穿于RNA的生命周期的所有阶段，通过影响RNA代谢发挥生物学功能。多项研究表明，m6A甲基化在急性白血病的起病、发展、耐药等多方面有着关键调控作用。m6A甲基化的研究也将为AL的治疗提供新的思路。本文就m6A甲基化及其在AL发生，发展，治疗耐药中的作用的研究进展作一综述.