Alleviation of synovitis caused by joint instability with application of platelet-rich plasma

Abstract

Introduction: Synovitis is an early set and persistent change during the progression of osteoarthritis, which causes symptoms such as pain and swelling of the joints. Platelet-rich plasma (PRP) can release quantities of growth factors and cytokines, and is proved effected in promoting restoration of multiple soft tissues.

Materials and methods: In this study, twenty rabbits were used to establish animal model of synovitis, with the method of severing the anterior and posterior cruciate ligaments and removing the medial meniscus. Then the rabbits were evenly divided into the PRP group and the control group, and each group received injections of PRP and saline respectively once a week for 3 weeks consecutively, with the first injection administered 3 weeks postoperatively.

Results: The platelet count, the concentrations of growth factors in PRP and whole blood were investigated, and the IL-1β concentration in the joint fluid was detected via ELISA. The synovium as well as the adjacent articular cartilage were collected for histological assessment. The platelet concentration in PRP is 6.8 fold of that in the whole blood. The IL-1β level in the PRP group was lower than that in the control group 2 and 3 weeks after the administration of PRP. Histological investigation showed that the inflammatory reaction of the synovium and impact on the cartilage was much abated in the PRP group.

Conclusions: PRP can effectively alleviate the synovitis caused by osteoarthritis following loss of joint stability. Given the autologous origin, its low cost and low risk features of PRP, it's a promising choice for OA patients to control the symptoms caused by synovitis.

Keywords: IL-1β; Platelet; Synovitis.