Targetability of STAT3-JAK2 fusions: implications for T-cell lymphoproliferative disorders of the gastrointestinal tract

Leukemia. 2020 May;34(5):1467-1471. doi: 10.1038/s41375-019-0678-3. Epub 2019 Dec 13.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis
  • Cell Proliferation
  • Gastrointestinal Neoplasms / complications*
  • Humans
  • Janus Kinase 2 / antagonists & inhibitors*
  • Lymphoma, T-Cell / drug therapy*
  • Lymphoma, T-Cell / metabolism
  • Lymphoma, T-Cell / pathology
  • Lymphoproliferative Disorders / drug therapy*
  • Lymphoproliferative Disorders / etiology
  • Lymphoproliferative Disorders / metabolism
  • Lymphoproliferative Disorders / pathology
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Nitriles
  • Oncogene Proteins, Fusion / antagonists & inhibitors
  • Protein Kinase Inhibitors / pharmacology
  • Pyrazoles / pharmacology*
  • Pyrimidines
  • STAT3 Transcription Factor / antagonists & inhibitors*
  • T-Lymphocytes / drug effects*
  • T-Lymphocytes / metabolism
  • T-Lymphocytes / pathology
  • Tumor Cells, Cultured
  • Xenograft Model Antitumor Assays

Substances

  • Nitriles
  • Oncogene Proteins, Fusion
  • Protein Kinase Inhibitors
  • Pyrazoles
  • Pyrimidines
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • ruxolitinib
  • JAK2 protein, human
  • Janus Kinase 2