SHP1 regulates a STAT6-ITGB3 axis in FLT3ITD-positive AML cells

Leukemia. 2020 May;34(5):1444-1449. doi: 10.1038/s41375-019-0676-5. Epub 2019 Dec 13.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis
  • Cell Proliferation
  • Gene Expression Regulation, Leukemic*
  • Humans
  • Integrin beta3 / genetics
  • Integrin beta3 / metabolism*
  • Leukemia, Myeloid, Acute / genetics
  • Leukemia, Myeloid, Acute / metabolism
  • Leukemia, Myeloid, Acute / pathology*
  • Mice
  • Mice, Inbred C3H
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6 / genetics
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6 / metabolism*
  • Repetitive Sequences, Nucleic Acid
  • STAT6 Transcription Factor / genetics
  • STAT6 Transcription Factor / metabolism*
  • Tumor Cells, Cultured
  • Xenograft Model Antitumor Assays
  • fms-Like Tyrosine Kinase 3 / genetics
  • fms-Like Tyrosine Kinase 3 / metabolism*

Substances

  • ITGB3 protein, human
  • Integrin beta3
  • STAT6 Transcription Factor
  • STAT6 protein, human
  • FLT3 protein, human
  • fms-Like Tyrosine Kinase 3
  • PTPN6 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6