FGF10 regulates thalamocortical axon guidance in the developing thalamus

Abstract

Thalamocortical axons (TCAs) transmit sensory information to the neocortex by responding to a variety of guidance cues in the environment. Similar to classical guidance cues (ephrins, slits, semaphorins and netrins), morphogens of FGFs can also help axons navigate to their targets. Here, expression analyses reveal that FGF10 is expressed in the chick prethalamus during the navigation of TCAs. Then, using ex vivo analyses in chick explants, we demonstrate a dose-dependent effect of FGF10 on thalamic axons: low concentration of FGF10 attracts thalamic axons, while high concentration FGF10 repels thalamic axons. Moreover, inhibition of FGF10 function indicates that FGF10 exerts a direct effect on thalamic axons. Together, these studies reveal a direct role for the member of FGF7 subfamily, FGF10, in the axonal navigation of TCAs.

Keywords: Axon guidance; FGF10; Thalamocortical axons; Thalamus.