RETRACTED: Knockdown PEG10 deteriorates H2O2-injury of PC-12 cells by targeting miR-34a-5p/TLX

Mol Immunol. 2020 Feb:118:1-8. doi: 10.1016/j.molimm.2019.11.012. Epub 2019 Dec 10.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. As originally reported in https://pubpeer.com/publications/9D9EBE8EAD0041A196D37E10E1BF18, Fig. 6I shows evidence of data manipulation, visible as patterns of repeated background artifacts in independent western blots that are unlikely to be the result of serendipity. The authors were contacted to investigate further the validity of these allegations and to provide the raw data but the journal received no response and therefore the Editor-in-Chief decided to retract the article.

Keywords: Smad and Wnt/β-catenin pathways; Spinal cord injury; TLX; lncRNA PEG10; miR-34a-5p.

Publication types

  • Retracted Publication

MeSH terms

  • Animals
  • Apoptosis / genetics
  • Cell Line, Tumor
  • Cell Movement / genetics
  • Cell Proliferation / genetics
  • Gene Expression Regulation, Neoplastic / genetics
  • Gene Knockdown Techniques / methods
  • Hydrogen Peroxide / pharmacology
  • MicroRNAs / genetics*
  • PC12 Cells
  • RNA, Long Noncoding / genetics*
  • Rats
  • Receptors, Cytoplasmic and Nuclear / genetics*
  • Wnt Signaling Pathway / genetics
  • beta Catenin / genetics

Substances

  • MIRN34 microRNA, rat
  • MicroRNAs
  • NR2E1 protein, rat
  • RNA, Long Noncoding
  • Receptors, Cytoplasmic and Nuclear
  • beta Catenin
  • Hydrogen Peroxide