How do you make new β-cells in humans? An attempt to create human β-cells from α-cells of brain-dead donors

J Diabetes Investig. 2020 May;11(3):513-515. doi: 10.1111/jdi.13197. Epub 2020 Jan 15.

Author

Yoshio Fujitani¹

Affiliation

¹ Laboratory of Developmental Biology and Metabolism, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.

Abstract

Ex vivo reprogramming of human α-cells toward functional β-cells by adenoviral transduction of key transcription factors.

© 2019 The Author. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.

Publication types

Editorial

MeSH terms

Cells, Cultured
Cellular Reprogramming Techniques / methods*
Diabetes Mellitus / physiopathology
Diabetes Mellitus / therapy*
Glucagon-Secreting Cells / physiology*
Humans
Insulin-Secreting Cells / physiology*
Tissue Donors

Grants and funding

MEXT/JSPS KAKENHI