1 Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN Department of Pharmacy, Mayo Clinic, Rochester, MN Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN.