Albanitriles A-G: Antiprotozoal Polyacetylene Nitriles from a Mycale Marine Sponge

Samuele Sala; Jane Fromont; Oliver Gomez; Daniel Vuong; Ernest Lacey; Gavin R Flematti

doi:10.1021/acs.jnatprod.9b00840

Albanitriles A-G: Antiprotozoal Polyacetylene Nitriles from a Mycale Marine Sponge

J Nat Prod. 2019 Dec 27;82(12):3450-3455. doi: 10.1021/acs.jnatprod.9b00840. Epub 2019 Dec 13.

Authors

Samuele Sala¹, Jane Fromont², Oliver Gomez², Daniel Vuong³, Ernest Lacey³, Gavin R Flematti¹

Affiliations

¹ School of Molecular Sciences , The University of Western Australia , Crawley , WA 6009 , Australia.
² Western Australian Museum , Welshpool , WA 6106 , Australia.
³ Microbial Screening Technologies Pty. Ltd. , Smithfield , NSW 2164 , Australia.

PMID: 31833368
DOI: 10.1021/acs.jnatprod.9b00840

Abstract

Seven new nitrile-bearing polyacetylenes, named albanitriles A-G, were isolated from a marine sponge of the Mycale genus (Order: Poecilosclerida, Family: Mycalidae) collected near Albany, Western Australia. Structural elucidation was achieved using a combination of high-resolution mass spectrometry and ultraviolet/visible, infrared, and nuclear magnetic resonance spectroscopy. The compounds were found to possess moderate activity against Giardia duodenalis when compared to a metronidazole positive control.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiprotozoal Agents / isolation & purification*
Antiprotozoal Agents / pharmacology*
Bacillus subtilis / drug effects
Candida albicans / drug effects
Drug Screening Assays, Antitumor
Escherichia coli / drug effects
Giardia lamblia / drug effects
Marine Biology*
Microbial Sensitivity Tests
Molecular Structure
Nitriles / chemistry
Nitriles / pharmacology*
Polyacetylene Polymer / chemistry
Polyacetylene Polymer / pharmacology*
Porifera / chemistry*
Spectrum Analysis / methods

Substances

Antiprotozoal Agents
Nitriles
Polyacetylene Polymer